Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride etherate → 6,7-Dichloro-5-methoxybenzo[b]thiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 6,7-Dichloro-2,3-dihydro-3-hydroxy-5-methoxybenzo[b]thiophene | HCID 13290214 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 6,7-Dichloro-5-methoxybenzo[b]thiophene | HCID 13289996 | 100% |
반응 단계
A mixture of 0.7 g of 6,7-dichloro-2,3-dihydro-3-hydroxy-5-methoxybenzo[b]thiophene, 1 ml of boron trifluoride etherate and 4 ml of glacial acetic acid is heated at 100° for 5 min. Ice is added and the mixture is basified with dilute sodium hydroxide solution. The off-white solid is collected or a filter, air-dried and recrystallized from ether-hexane to give 0.65 g of 6,7-dichloro-5-methoxybenzo[b]thiophene as prisms, mp 103°-104.5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04528399 |
| 출처 데이터셋 | uspto-grants-1985_07 |
| ORD ID | ord-a7a1e58dfbae40dcbc89bd7f1a4472f8 |
| 출처 메모 | uspto-grants-1985_07 |