Potassium Hydroxide → Dimethyl (2-methoxy-phenylsulphanyl)malonate

HRID 37101

반응식

HRID 37101 반응식
[OH-].[K+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[SH:11].Cl[CH:13]([C:18]([O:20][CH3:21])=[O:19])[C:14]([O:16][CH3:17])=[O:15]>C(O)C>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:13]([C:18]([O:20][CH3:21])=[O:19])[C:14]([O:16][CH3:17])=[O:15]

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 23642ThioguaiacolHCID 120070Dimethyl chloromalonate

생성물 1

HCID 22362038Dimethyl (2-methoxy-phenylsulphanyl)malonate

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

1 g of KOH was added to a solution of 2.2 ml of 2-methoxythiophenol in 30 ml of ethanol. The reaction mixture was treated at room temperature with a solution of dimethyl chloromalonate in 5 ml of ethanol, stirred for 1 hour and evaporated. The residue was partitioned between ether and water. The organic phase was dried, concentrated and the residue was purified over silica gel with methylene chloride. 3.6 g of dimethyl (2-methoxy-phenylsulphanyl)malonate, MS: M=270, were obtained.

후처리

  1. customevaporated
  2. customThe residue was partitioned between ether and water
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customthe residue was purified over silica gel with methylene chloride

출처 및 근거

ORD 기록
ord-19e57d3a32fb454487ce6ca1e155c744
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420129

연결된 노트

불러오는 중…