Acetic Acid → 1,3-Butanedione, 1-(2-furanyl)-

HRID 371090

반응식

HRID 371090 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8]C)=O.[CH3:10][C:11]([CH3:13])=[O:12].CC(C)([O-])C.[K+].C(O)(=O)C>C1(C)C=CC=CC=1.O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:8])[CH2:10][C:11](=[O:12])[CH3:13]

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 180AcetoneHCID 11902Methyl 2-furoateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 121681,3-Butanedione, 1-(2-furanyl)-

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

A mixture of methyl 2-furoate (23 g, 0.18 mole) and acetone (10.6 g, 0.18 mole) was slowly added to a stirred suspension of potassium tert-butoxide (41 g, 0.36 mole) in anhydrous toluene (300 ml) at 0° C. Upon standing overnight at room temperature, glacial acetic acid (22 ml, 0.36 mole) and then water (100 ml) were added. The organic layer was separated, combined with an ether extract of the aqueous phase, washed with water, dried, and distilled to give 1-(2-furyl)-1,3-dioxobutane: b.p. 66°-70° C./0.1 mm (18.5 g).

후처리

  1. customThe organic layer was separated
  2. extractionextract of the aqueous phase
  3. washwashed with water
  4. customdried
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-7805c0baa15549b38d0828aa8c242789
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04529733

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