Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ketoprofen → Phthalidyl 2-(3-benzoylphenyl)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ketoprofen | HCID 3825 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1(3H)-Isobenzofuranone, 3-bromo- | HCID 96218 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Phthalidyl 2-(3-benzoylphenyl)propionate | HCID 12769703 | 79% |
반응 단계
To a solution of 7.6 g of 2-(3-benzoylphenyl)propionic acid in 30 ml of chloroform and 3.4 g of triethylamine is added a solution of 6.2 g of 3-bromophthalide in 20 ml of chloroform. The solution thus obtained is stirred 25 hours at room temperature, the organic phase is washed with an aqueous solution of sodium bicarbonate, then with water and finally dried on anhydrous sodium sulfate and evaporated to dryness to give the phthalidyl 2-(3-benzoylphenyl)propionate; yield 79%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04529737 |
| 출처 데이터셋 | uspto-grants-1985_07 |
| ORD ID | ord-13e304f3ba35400987a80225de0e105e |
| 출처 메모 | uspto-grants-1985_07 |