Potassium Carbonate → N-(2-Propynyl)-cis-2-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol

HRID 371164

반응식

HRID 371164 반응식
[CH3:1][C:2]([C:10]1[CH:15]=[CH:14][C:13]([C@H:16]2[CH2:21][C@@H:20]([OH:22])[CH2:19][CH2:18][NH:17]2)=[C:12]([OH:23])[CH:11]=1)([CH3:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:24](Br)#[C:25][CH3:26].C(=O)([O-])[O-].[K+].[K+]>>[CH2:26]([N:17]1[CH2:18][CH2:19][C@H:20]([OH:22])[CH2:21][C@@H:16]1[C:13]1[CH:14]=[CH:15][C:10]([C:2]([CH3:1])([CH3:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[CH:11][C:12]=1[OH:23])[C:25]#[CH:24]

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 1372791-Propyne, 1-bromo-HCID 13519478cis-2-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol

생성물 1

HCID 86740205N-(2-Propynyl)-cis-2-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol수율 57%

실험 절차

Employing the procedure of Example 10 with 321 mg (1.01 mmole) of cis-2-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol, 82 microliter (1.06 mmole) or propynyl bromide and 292 mg (2.12 mmole) of potassium carbonate affords 205 mg (57%) of the title compound as an oil.

출처 및 근거

ORD 기록
ord-369fd318923a4ab2b381bdc985bb373d
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04529732

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