Glycolic Acid → 4,4'-Methylenebis(hydroxyacetamidocyclohexane)

HRID 371173

반응식

HRID 371173 반응식
[CH2:1]([CH:9]1[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]1)[CH:2]1[CH2:7][CH2:6][CH:5]([NH2:8])[CH2:4][CH2:3]1.[C:16]([OH:20])(=O)[CH2:17][OH:18]>O>[CH2:1]([CH:2]1[CH2:3][CH2:4][CH:5]([NH:8][C:16](=[O:20])[CH2:17][OH:18])[CH2:6][CH2:7]1)[CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][C:17](=[O:18])[CH2:16][OH:20])[CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 757Glycolic AcidHCID 156604,4'-Diaminodicyclohexylmethane

생성물 1

HCID 542181664,4'-Methylenebis(hydroxyacetamidocyclohexane)수율 87%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

4,4'-Methylenebis(cyclohexylamine) (25 g, 0.12 mole) and glycolic acid (18.2 g, 0.24 mole) were combined in a 250 ml round bottom flask heated in an oil bath. The solids were melted together with mixing and heated to 175° C. whereupon distillation of water occurred. After heating for 3 hours the evolution of water subsided and crystallization commenced. The solid was removed and recrystallized from methanol to yield 34 g (87%) of lustrous white needles; m.p. 208°-212° C.

후처리

  1. temperatureheated in an oil bath
  2. additionwith mixing
  3. customcrystallization
  4. customThe solid was removed
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-2bd0f103b0b04ca6a0b7d61ad900734e
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04529792

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