Methanol → Methyl 3-Hydroxyphenylacetate

HRID 37129

반응식

HRID 37129 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH3:17]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 121223'-Hydroxyphenylacetic acid

생성물 1

HCID 39129Methyl 3-Hydroxyphenylacetate수율 71%

실험 절차

To a solution of 3-hydroxyphenylacetic acid (2 g, 13.2 mmol) in methanol (45 mL) was added concentrated H2SO4 (0.82 mL) and the mixture was heated at reflux for 18 h. Next, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and the solvent was removed, to yield 1.54 g of the desired compound (yield: 71%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 h
  3. customNext, the solvent was removed
  4. additionthe residue was diluted with water
  5. extractionextracted with ethyl acetate
  6. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  7. customthe solvent was removed

출처 및 근거

ORD 기록
ord-bf58182e499b4b8590ee23072ae2a58a
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420131

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