4-Toluenesulfonyl chloride → 4-Propionylpyridine oxime tosylate

HRID 371400노트

반응식

HRID 371400 반응식
[C:1](=[N:10][OH:11])([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)[CH2:2][CH3:3].[C:12]1([CH3:22])[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>N1C=CC=CC=1>[S:18]([C:15]1[CH:16]=[CH:17][C:12]([CH3:22])=[CH:13][CH:14]=1)([OH:11])(=[O:20])=[O:19].[C:1](=[N:10][OH:11])([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 1363417421-(Pyridin-4-yl)propan-1-one oxime

생성물 1

HCID 1363872634-Propionylpyridine oxime tosylate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To the oxime 2 of Example 2 (5.0 g, 33 mmol) dissolved in pyridine (31 mL) was added p-toluenesulfonyl chloride (7.4 g, 39 mmol) and the reaction mixture stirred at room temperature for 24 hours. Pyridine hydrochloride was removed by filtration and the filtrate concentrated under reduced pressure. The solid obtained was slurried in hexanes, filtered, and air dried to give the compound 3 as a pale peach-colored solid: NMR (CDCl3) δ 1.12 (t, 3H, J=8 Hz), 2.45 (s, 3H), 2.81 (q, 2H, J=8 Hz), and 7.27-7.98 (m, 8H).

후처리

  1. customPyridine hydrochloride was removed by filtration
  2. concentrationthe filtrate concentrated under reduced pressure
  3. customThe solid obtained
  4. filtrationfiltered
  5. customair dried

출처 및 근거

ORD 기록
ord-f2d87eba931649f592dc6d67dec8dc33
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04532250

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