1-Benzylpiperazine → 6-Methyl-5-[4-(phenylmethyl)-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione

HRID 371454

반응식

HRID 371454 반응식
Br[C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:9])[NH:6][C:7]=1[CH3:8].O.O.[F-].[K+].[CH2:15]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:8][C:7]1[NH:6][C:5](=[O:9])[NH:4][C:3](=[O:10])[C:2]=1[N:25]1[CH2:26][CH2:27][N:22]([CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:23][CH2:24]1

참가 물질

4

반응물 3

HCID 759941-BenzylpiperazineHCID 847572,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-HCID 23708904Potassium fluoride dihydrate

생성물 1

HCID 134783296-Methyl-5-[4-(phenylmethyl)-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione

실험 절차

A mixture of 20.5 g (0.10 mole) of 5-bromo-6-methyl-2,4(1H,3H)pyrimidinedione and 10.3 g (0.11 mole) of potassium fluoride dihydrate in 130 ml of 1-benzylpiperazine was heated under reflux for 72 hours. The reaction mixture was then cooled and poured into 800 ml of ice water. The solid which formed was collected and washed with water to give 8.10 g of the product as an off-white solid. A 1.0 g portion of the crude product was recrystallized from methanol to give an off-white solid, mp 263° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 72 hours
  3. temperatureThe reaction mixture was then cooled
  4. customThe solid which formed
  5. customwas collected
  6. washwashed with water

출처 및 근거

ORD 기록
ord-b268680494234b9691676094c3fcf777
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04532240

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