6-Methyluracil → 2,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-

HRID 371455

반응식

HRID 371455 반응식
[Br:1]Br.[CH3:3][C:4]1[NH:9][C:8](=[O:10])[NH:7][C:6](=[O:11])[CH:5]=1>C(O)(=O)C>[Br:1][C:5]1[C:6](=[O:11])[NH:7][C:8](=[O:10])[NH:9][C:4]=1[CH3:3]

참가 물질

4

반응물 2

HCID 122836-MethyluracilHCID 24408Bromine

생성물 1

HCID 847572,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-수율 77.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Bromine (39.97 g, 0.25 mole) was added dropwise to a cooled mixture of 31.5 g (0.25 mole) of 6-methyl-2,4(1H,3H)pyrimidinedione in 200 ml of glacial acetic acid. The resulting mixture was stirred at ambient temperature for 16 hours and then filtered. The solid which was collected was washed with water and dried in vacuo overnight at 69° C. to give 39.9 g of the product as a white solid, mp 254° C. (dec.).

후처리

  1. filtrationfiltered
  2. customThe solid which was collected
  3. washwas washed with water
  4. customdried in vacuo overnight at 69° C.

출처 및 근거

ORD 기록
ord-75d36cdee415432186b42c2d574b37a0
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04532240

연결된 노트

불러오는 중…