Nitric Acid → HCID 13489933, 화합물

반응식

[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[N+:13]([O-])([OH:15])=[O:14]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([N+:13]([O-:15])=[O:14])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 127123362-Chloro-1-methyl-3-(trifluoromethyl)benzene

생성물 1

HCID 13489933HCID 13489933, 화합물수율 98.1%

실험 절차

72 gms of the crude mixture of 2, 4, and 6 mono chloro 3-methyl benzotrifluoride (0.37 moles) from Example I was added dropwise to 200 gms of 98% HNO3 at about -5° C. to 0° C. over a period of about 1 hour. After addition, solution was stirred for an additional 20 minutes. The solution was then washed with ice water and solvent extracted with CH2Cl2 to give 87 gms of an amber colored liquid. The liquid was distilled at 100°-110° C./(<0.1 mm) to give 84.5 gms of a yellow colored liquid (96% yield)

후처리

additionAfter addition, solution
washThe solution was then washed with ice water and solvent
extractionextracted with CH2Cl2

출처 및 근거

ORD 기록: ord-6d2d8151a06b463a910ec5abd86431d7
출처 데이터셋: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04532353

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