Sodium Cyanide → 1-Cyanomethyl-3-methyl-4-phenylthiobenzene

HRID 37152노트

반응식

HRID 37152 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:16])[CH:4]=1.[C-:17]#[N:18].[Na+]>CN(C)C=O.[Cl-].[Na+].O>[C:17]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:16])[CH:4]=1)#[N:18]

참가 물질

5

반응물 2

HCID 8929Sodium CyanideHCID 199346681-Chloromethyl-3-methyl-4-phenylthiobenzene

생성물 1

HCID 199346671-Cyanomethyl-3-methyl-4-phenylthiobenzene

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 57417360Sodium chloride; water용매

실험 절차

Thus obtained 1-chloromethyl-3-methyl-4-phenylthiobenzene was dissolved in 56 ml of N,N-dimethylformamide, and 18.16 g of finely ground sodium cyanide was added, and the mixture was stirred overnight at room temperature. After adding 300 ml of saturated brine and 300 ml of ice water to the reaction mixture, it was extracted with ethyl acetate (300 ml×3). The extract was washed with saturated brine (200 ml×3), and dried with anhydrous sodium sulfate, concentrated in vacuo, and 1-cyanomethyl-3-methyl-4-phenylthiobenzene was obtained (45.95 g).

후처리

  1. extractionwas extracted with ethyl acetate (300 ml×3)
  2. washThe extract was washed with saturated brine (200 ml×3)
  3. dry with materialdried with anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8921fb5be03740e0b38ffc31f96ed2a5
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420128

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