Tetrahydrofuran → 1-Diallylcarbamoyl-3-isopropylsulphinyl-1,2,4-triazole

HRID 371577노트

반응식

HRID 371577 반응식
[CH:1]([S:4]([C:6]1[N:10]=[CH:9][NH:8][N:7]=1)=[O:5])([CH3:3])[CH3:2].[CH2:11]([N:14]([CH2:18][CH:19]=[CH2:20])[C:15](Cl)=[O:16])[CH:12]=[CH2:13].O1CCCC1>C(N(CC)CC)C>[CH2:11]([N:14]([CH2:18][CH:19]=[CH2:20])[C:15]([N:8]1[CH:9]=[N:10][C:6]([S:4]([CH:1]([CH3:3])[CH3:2])=[O:5])=[N:7]1)=[O:16])[CH:12]=[CH2:13]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 3449313Diallylcarbamyl chlorideHCID 1784610013-Isopropylsulphinyl-1,2,4-triazole

생성물 1

HCID 203550491-Diallylcarbamoyl-3-isopropylsulphinyl-1,2,4-triazole

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A mixture of 6.4 g. 3-isopropylsulphinyl-1,2,4-triazole, 8.0 ml. diallylcarbamoyl chloride, 25 ml. dry tetrahydrofuran and 10 ml. dry triethylamine was refluxed under anhydrous conditions for 2 hours. The cooled reaction mixture was filtered and the filtrate was distilled under reduced pressure to give an oily residue which subsequently solidified. This solid residue was recrystallized from petroleum ether (b.p. 60° - 80° C.) to give 1-diallylcarbamoyl-3-isopropylsulphinyl-1,2,4-triazole, m.p. 32° - 34° C. Elemental analysis satisfactory.

후처리

  1. additionA mixture of 6.4 g
  2. customThe cooled reaction mixture
  3. filtrationwas filtered
  4. distillationthe filtrate was distilled under reduced pressure
  5. customto give an oily residue which
  6. customThis solid residue was recrystallized from petroleum ether (b.p. 60° - 80° C.)

출처 및 근거

ORD 기록
ord-0ae279299cf94091a3ecb629d3ed6a15
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087269

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