Tetrahydrofuran → 1-Dipropylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole

HRID 371579노트

반응식

HRID 371579 반응식
[CH2:1]([S:5]([C:7]1[N:11]=[CH:10][NH:9][N:8]=1)=[O:6])[CH2:2][CH2:3][CH3:4].[CH2:12]([N:15]([CH2:19][CH2:20][CH3:21])[C:16](Cl)=[O:17])[CH2:13][CH3:14].O1CCCC1>C(N(CC)CC)C>[CH2:12]([N:15]([CH2:19][CH2:20][CH3:21])[C:16]([N:9]1[CH:10]=[N:11][C:7]([S:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[O:6])=[N:8]1)=[O:17])[CH2:13][CH3:14]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 3015348Dipropylcarbamoyl chlorideHCID 1784555543-Butylsulphinyl-1,2,4-triazole

생성물 1

HCID 202901461-Dipropylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A mixture of 6.9 g. 3-n-butylsulphinyl-1,2,4-triazole, 8.0 ml. dipropylcarbamoyl chloride, 25 ml. dry tetrahydrofuran and 10 ml. dry triethylamine was refluxed under anhydrous conditions for 2 hours. The cooled reaction mixture was filtered and the filtrate distilled under reduced pressure to give an oily residue which subsequently solidified. This solid product was recrystallized from petroleum ether to give 1-dipropylcarbamoyl-3-n-butylsulphinyl-1,2,4-triazole, m.p. 39° - 40° C. Elemental analysis satisfactory.

후처리

  1. additionA mixture of 6.9 g
  2. customThe cooled reaction mixture
  3. filtrationwas filtered
  4. distillationthe filtrate distilled under reduced pressure
  5. customto give an oily residue which
  6. customThis solid product was recrystallized from petroleum ether

출처 및 근거

ORD 기록
ord-b829549a029a4044af0efdc3bd1bd04c
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087269

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