Ethanol → 3-(Ethoxycarbonyl)benzoic acid

HRID 371609노트

반응식

HRID 371609 반응식
[C:1]([O:14]CC)(=[O:13])[C:2]1[CH:12]=[CH:11][CH:10]=[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH:3]=1.C(O)C.[OH-].[K+]>O>[C:5]([O:7][CH2:8][CH3:9])(=[O:6])[C:4]1[CH:10]=[CH:11][CH:12]=[C:2]([C:1]([OH:14])=[O:13])[CH:3]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 12491Diethyl isophthalateHCID 14797Potassium Hydroxide

생성물 1

HCID 8167713-(Ethoxycarbonyl)benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 55 g. of this diethyl isophthalate in 140 ml. of ethanol was saponified by the addition of 15 g. of potassium hydroxide in 15 ml. of water. The resulting gel was refluxed 30 minutes, cooled and extracted with ether to remove unreacted diester. The water layer was acidified and the crude acid product precipitated. Ethyl hydrogen isophthalate having a melting point of 131° to 132° C. was obtained in a 16.5 g. yield after recrystallization from benzene.

후처리

  1. temperatureThe resulting gel was refluxed 30 minutes
  2. temperaturecooled
  3. extractionextracted with ether
  4. customto remove unreacted diester
  5. customthe crude acid product precipitated

출처 및 근거

ORD 기록
ord-d5a50fb553ec478ab321549326c6685c
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087409

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