Sodium Methoxide → Methyl 6-hydroxy-1,4-benzodioxin-2-carboxylate

HRID 37162노트

반응식

HRID 37162 반응식
C[O-].[Na+].C([O:7][C:8]1[CH:22]=[CH:21][C:11]2[O:12][C:13]([C:16]([O:18][CH2:19]C)=[O:17])=[CH:14][O:15][C:10]=2[CH:9]=1)(=O)C>CO>[OH:7][C:8]1[CH:22]=[CH:21][C:11]2[O:12][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][O:15][C:10]=2[CH:9]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 11043631HCID 11043631, 화합물

생성물 1

HCID 19392464Methyl 6-hydroxy-1,4-benzodioxin-2-carboxylate수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Add 3.8 mmol of a 2M solution of sodium methanolate to a solution of 0.38 mmol of ethyl 6-acetoxy -1,4-benzodioxin-2-carboxylate in 5 cm3 of anhydrous methanol. After stirring for 4 hours at room temperature and neutralising with acid Dowex resin, the reaction mixture is concentrated under reduced pressure and the crude product obtained is purified by chromatography on a silica column (eluant:petroleum ether/diethyl ether, 80:20). Methyl 6-hydroxy -1,4-benzodioxin-2-carboxylate is thereby obtained in a yield of 87%.

후처리

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. customthe crude product obtained
  3. customis purified by chromatography on a silica column (eluant:petroleum ether/diethyl ether, 80:20)

출처 및 근거

ORD 기록
ord-f515a5cd05e14bb88cf63db093e027f9
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420132

반응 노트

불러오는 중…