1-(Bis(4-fluorophenyl)methyl)piperazine → 6-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-2,3-dihydro-1,4-benzodioxin

HRID 37166

반응식

HRID 37166 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[OH:22][C:23]1[CH:35]=[CH:34][C:26]2[O:27][CH:28]([C:31](O)=[O:32])[CH2:29][O:30][C:25]=2[CH:24]=1>>[OH:22][C:23]1[CH:35]=[CH:34][C:26]2[O:27][CH:28]([C:31]([N:12]3[CH2:11][CH2:10][N:9]([CH:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)[C:15]4[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=4)[CH2:14][CH2:13]3)=[O:32])[CH2:29][O:30][C:25]=2[CH:24]=1

참가 물질

3

반응물 2

HCID 1529321-(Bis(4-fluorophenyl)methyl)piperazineHCID 108780626-Hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid

생성물 1

HCID 117623936-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-2,3-dihydro-1,4-benzodioxin수율 80%

실험 절차

That compound is obtained a yield of 80% starting from 1-[bis(4-fluorophenyl)methyl]piperazine and 6-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid.

후처리

  1. customThat compound is obtained a yield of 80%

출처 및 근거

ORD 기록
ord-f5a152932e154c3bae7a278924305675
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420132

연결된 노트

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