Cyclohexene → Ethyl 2-[(3-amino-2-cyanophenyl)amino]-2-oxoacetate
반응식
[CH2:1]([O:3][C:4](=[O:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[C:9]=1[C:17]#[N:18])=[O:6])[CH3:2].C1CCCCC=1>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[C:9]=1[C:17]#[N:18])=[O:6])[CH3:2]참가 물질
5
실험 절차
The title compound is prepared by reduction of [3-nitro-2-cyanophenylamino]oxoacetic acid ethyl ester with 10% Pd. on charcoal and with cyclohexene in ethanol according to the procedure of I. D. Entwistle and R. A. W. Johnstone, J. Chem. Soc., Perkin I, 1300 (1975). The crude product is chromatographed on silica gel with chloroform and recrystallized from ethanol, m.p. 133°-136° C.
후처리
- customThe crude product is chromatographed on silica gel with chloroform
- customrecrystallized from ethanol, m.p. 133°-136° C.
출처 및 근거
- ORD 기록
- ord-739b61f659d247319956cde1ac419e8b
- 출처 데이터셋
- uspto-grants-1978_05
- 특허 번호
- US04087606
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