Methane → 5-Bromo-N-methanesulfonylpentanamide

HRID 371767

반응식

HRID 371767 반응식
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].C>C(Cl)Cl>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 297MethaneHCID 72879MethanesulfonamideHCID 5211735-Bromovaleryl chloride

생성물 1

HCID 202961415-Bromo-N-methanesulfonylpentanamide수율 86%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 0.950g (0.01 mole) of methanesulfonamide and 1.80 g. (0.01 mole) of 5-bromovaleric acid chloride was heated on a steam bath until gas evolution ceased (ca. 5 minutes). The brown reaction mixture was allowed to cool and was dissolved in methylene chloride. The methylene chloride solution was treated with Darco, was filtered, and was diluted with hexane with cooling to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 2.22 g. (86.0% yield) which melted at 88°-89°.

후처리

  1. custom(ca. 5 minutes)
  2. temperatureto cool
  3. filtrationwas filtered
  4. additionwas diluted with hexane
  5. temperaturewith cooling

출처 및 근거

ORD 기록
ord-6fe8181ee96f41b8a0150e58aa944655
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087604

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