Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 19-t-Butyldimethylsiloxy-4-androstene-3,17-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | 19-Hydroxyandrostenedione | HCID 252379 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 19-t-Butyldimethylsiloxy-4-androstene-3,17-dione | HCID 10573974 | — |
반응 단계
19-Hydroxy-4-androstene-3,17-dione, t-butyldimethylsilylchloride and pyridine are mixed in dry dimethylformamide and heated on a steam bath overnight. The reaction mixture is poured onto water and stirred well for 15 minutes. The resulting solid is filtered and dissolved in methylenechloride, dried over magnesium sulfate and the solvent removed. The residue is crystallized from an acetone-hexane solution to yield 19-t-butyldimethylsiloxy-4-androstene-3,17-dione.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04087524 |
| 출처 데이터셋 | uspto-grants-1978_05 |
| ORD ID | ord-0d06e6505c2c4bc38a1a215cd98f8202 |
| 출처 메모 | uspto-grants-1978_05 |