Sodium Carbonate → 17beta,19-Dihydroxy-1alphamethyl-4-androsten-3-one

HRID 371839노트

반응식

HRID 371839 반응식
C(O)(=O)CC.C(O)(=O)CC.[OH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]2[C@H:18]3[C@H:29]([CH2:30][CH2:31][C@:13]12[CH3:14])[C@:26]1([CH2:27][OH:28])[C:21](=[CH:22][C:23](=[O:33])[CH2:24][C@@H:25]1[CH3:32])[CH2:20][CH2:19]3.C(=O)([O-])[O-].[Na+].[Na+]>CO>[OH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]2[C@H:18]3[C@H:29]([CH2:30][CH2:31][C@:13]12[CH3:14])[C@:26]1([CH2:27][OH:28])[C:21](=[CH:22][C:23](=[O:33])[CH2:24][C@@H:25]1[CH3:32])[CH2:20][CH2:19]3

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 8673472917beta,19-Dihydroxy-1alpha-methyl-4-androsten-3-one dipropionate

생성물 1

HCID 2279742517beta,19-Dihydroxy-1alphamethyl-4-androsten-3-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 17β,19-dihydroxy-1α-methyl-4-androsten-3-one dipropionate in methanol is refluxed for two hours with aqueous sodium carbonate. The solvent is removed and the residue dissolved in chloroform. The chloroform solution is washed well with water, dried over magnesium sulfate and evaporated under vacuum. The residue which remains in crystallized from acetonitrile to yield 17β,19-dihydroxy-1α-methyl-4-androsten-3-one.

후처리

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in chloroform
  3. washThe chloroform solution is washed well with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated under vacuum
  6. customin crystallized from acetonitrile

출처 및 근거

ORD 기록
ord-f8042fc939c3450a8463ef2ff819279b
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04087524

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