Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methylbenzoic acid → 3-Methylbenzoyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methylbenzoic acid | HCID 7418 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 3-Methylbenzoyl chloride | HCID 74375 | — |
반응 단계
Meanwhile, the 3-methylbenzoyl chloride acylating agent was prepared by suspending 3.016 g (22.0 mmol) of m-toluic acid in 100 ml benzene. To this solution was added 2.0 equiv. (3.84 ml) of oxalyl chloride, dropwise via a pressure-equalizing dropping funnel at O° C. DMF (2-3 drops) was added to the reaction mixture catalytically and the ice bath was removed. The progress of the reaction was monitored via infrared spectroscopy. The solvent was removed by rotary vacuum evaporation and the residual oil was pumped down under high vacuum overnight.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420134 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-327c30f17ea74844a93444c148790f2c |
| 출처 메모 | uspto-grants-1995_05 |