Water → 2-[p-(2,4-Dichlorobenzyl)-phenoxi]-butyric acid ethyl ester

HRID 371891노트

반응식

HRID 371891 반응식
[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH2:17]([O:19][C:20](=[O:25])[CH:21](Cl)[CH2:22][CH3:23])[CH3:18].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:17]([O:19][C:20](=[O:25])[CH:21]([O:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3]2[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:2]=2[Cl:1])=[CH:10][CH:9]=1)[CH2:22][CH3:23])[CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 123252Ethyl 2-chlorobutanoateHCID 139387094-(2,4-Dichlorobenzyl)-phenol

생성물 1

HCID 706231782-[p-(2,4-Dichlorobenzyl)-phenoxi]-butyric acid ethyl ester수율 45.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 25.3 g of 4-(2,4-dichlorobenzyl)-phenol and 15 g of α-chlorobutyric acid ethyl ester in 100 ml of dimethyl formamide were stirred for 2 hours at 100° C with 16 g of potassium carbonate. After cooling, the reaction mixture was poured into 1 liter of water. An oil precipitated which was separated and dried over sodium sulfate. By vacuum distillation, 16.8 g of 2-[p-(2,4-dichlorobenzyl)-phenoxi]-butyric acid ethyl ester were obtained. b.p. 180° - 183° C/0.8 mm Hg/nD21 : 1.5912 ##STR7## The following compounds were prepared according to the methods described in the above Examples.

후처리

  1. temperatureAfter cooling
  2. customAn oil precipitated which
  3. customwas separated
  4. dry with materialdried over sodium sulfate
  5. distillationBy vacuum distillation

출처 및 근거

ORD 기록
ord-90f266f1bf5e4a3fb18e4471427ba76a
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04088474

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