Sodium Carbonate → 3-(5-Norbornen-2-ylcarbonyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

HRID 371945

반응식

HRID 371945 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:13][CH:12]2[CH2:11][NH:10][CH2:9]3)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH:20]12[CH2:26][CH:23]([CH:24]=[CH:25]1)[CH2:22][CH:21]2[C:27](Cl)=[O:28]>>[CH:20]12[CH2:26][CH:23]([CH:24]=[CH:25]1)[CH2:22][CH:21]2[C:27]([N:10]1[CH2:11][CH:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)([CH2:13]2)[CH2:9]1)=[O:28]

참가 물질

4

반응물 3

HCID 10340Sodium CarbonateHCID 98233Bicyclo(2.2.1)hept-5-ene-2-carbonyl chlorideHCID 101303311-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane

생성물 1

HCID 203522403-(5-Norbornen-2-ylcarbonyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

실험 절차

Following the procedure of Example 8, 19.53 g. of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g. of sodium carbonate and 5-norbornene-2-carbonyl chloride are reacted to give the product as a light brown-yellow oily gum.

출처 및 근거

ORD 기록
ord-09e123c51cad4810b26e69dbfca74b65
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04088652

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