Water → 1-Chloro-3-phenoxypropan-2-one

HRID 372070

반응식

HRID 372070 반응식
CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O.[Cl:14][CH2:15][CH:16]([OH:25])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O.[Cr]>[Cl:14][CH2:15][C:16]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:25]

참가 물질

6

반응물 3

HCID 962WaterHCID 943001-Chloro-3-phenoxy-2-propanolHCID 131709961Jones' reagent

생성물 1

HCID 116224561-Chloro-3-phenoxypropan-2-one수율 49.7%

시약·촉매·용매 2

HCID 23976Chromium촉매HCID 180Acetone용매

반응 조건

온도
20 °C

실험 절차

8N Jones reagent (100 ml.) was added dropwise to a stirred solution of 1-chloro-2-hydroxy-3-phenoxypropane (28.3 g.) in acetone (100 ml.) during 1 hour while maintaining the reaction temperature at 20° C. The mixture was then stirred for 4 hours, and then sufficient water was added to dissolve the precipitated chromium salts. The mixture was extracted three times with diethyl ether and the combined ethereal extracts were dried over sodium sulphate, concentrated under reduced pressure, dried again over sodium sulphate, and concentrated further and distilled, to give 1-chloro-3-phenoxyacetone (13.9 g.), b.p. 150°-155° C./20 mm.Hg.

후처리

  1. extractionThe mixture was extracted three times with diethyl ether
  2. dry with materialthe combined ethereal extracts were dried over sodium sulphate
  3. concentrationconcentrated under reduced pressure
  4. dry with materialdried again over sodium sulphate
  5. concentrationconcentrated further
  6. distillationdistilled

출처 및 근거

ORD 기록
ord-aebca0dd54214c77b0232d4af4effbc5
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04088695

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