Tetrahydrofuran → 4-[(2-Butyl imidazo(1,2-a)pyridine 3-yl) methyl]benzonitrile

HRID 37212노트

반응식

HRID 37212 반응식
Br[C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[CH2:11][CH2:12][CH2:13][CH3:14].O1[CH2:19][CH2:18][CH2:17][CH2:16]1>[Pd].BrCC1C=CC(C#N)=CC=1.[Zn].O>[CH2:11]([C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[C:2]=1[CH2:16][C:17]1[CH:13]=[CH:12][C:11]([C:3]#[N:4])=[CH:19][CH:18]=1)[CH2:12][CH2:13][CH3:14]

참가 물질

6

반응물 2

HCID 8028TetrahydrofuranHCID 151299083-Bromo-2-butylimidazo[1,2-a]pyridine

생성물 1

HCID 190324684-[(2-Butyl imidazo(1,2-a)pyridine 3-yl) methyl]benzonitrile

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 69459885HCID 69459885, 화합물촉매HCID 962Water용매

실험 절차

A mixture of 2 g of the product of Stage D, 100 ml of tetrahydrofuran and 1 -g of [tetra-bis(triphenylphosphine)] palladium was added to 35.9 ml of zinc 4-bromomethyl benzonitrile at ambient temperature and the mixture was refluxed for one hour. The mixture was allowed to return to ambient temperature, poured into water and extracted with ethyl acetate. The extracts were washed with a saturated aqueous solution of sodium chloride, dried, filtered and brought to dryness to obtain after chromatography on silica (ethyl acetate), 1.1 g of the expected product.

후처리

  1. temperaturethe mixture was refluxed for one hour
  2. customto return to ambient temperature
  3. extractionextracted with ethyl acetate
  4. washThe extracts were washed with a saturated aqueous solution of sodium chloride
  5. customdried
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-548804b8b0344758893f2d65a8348415
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420138

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