Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminopyridine → 2-Methylimidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | Bromoacetone | HCID 11715 | — |
| 반응물 | 1,1-Dimethylethyl 4'-[(2-butyl 4,5,6,7-tetrahydro pyrazolo(1,5-a)pyridin-3-yl)methyl](1,1'-biphenyl)2-carboxylate | HCID 19032469 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-Methylimidazo[1,2-a]pyridine | HCID 136742 | 245.9% |
반응 단계
A mixture of 5 g of 2-amino pyridine and 250 ml of acetone were added at ambient temperature to a mixture of 7.25 g of 1 bromo 2-propanone and 20 ml of acetone and the mixture was refluxed for 30 minutes. Using the procedure of Stage C of Example 22, 5.3 g of the expected product were obtained in the form of an orange oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420138 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-a3c2d8350f0a4600b896fc04423ca462 |
| 출처 메모 | uspto-grants-1995_05 |