Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-3-methylpyridine → alpha-(Ethoxycarbonyl-methyl)-beta-(3-methyl-2-pyridyl-amino)-acrylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-3-methylpyridine | HCID 15347 | — |
| 반응물 | 1,4-Diethyl 2-formylbutanedioate | HCID 231500 | — |
| 생성물 | alpha-(Ethoxycarbonyl-methyl)-beta-(3-methyl-2-pyridyl-amino)-acrylic acid ethyl ester | HCID 70619341 | 65% |
반응 단계
10.8 g. (0.1 mole) of 3-methyl-2-amino-pyridine are admixed with 20.2 g. (0.1 mole) of 2-formyl-succinic acid diethyl ester. The reaction mixture warms up to 40°-50° C. The mixture is stirred for an hour, whereupon it is allowed to stand at room temperature overnight. The α-(ethoxycarbonyl-methyl)-β-(3-methyl-2-pyridyl-amino)-acrylic acid ethyl ester thus obtained is recrystallized from 50% aqueous ethanol. Yield: 65-70%, m.p.: 62° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04089858 |
| 출처 데이터셋 | uspto-grants-1978_05 |
| ORD ID | ord-37d8a42d71104478b265933297230749 |
| 출처 메모 | uspto-grants-1978_05 |