Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Hydroxyacetamide | HCID 69021 | — |
| 반응물 | 2-(4-Chloro-2-methylphenoxy)acetaldehyde | HCID 12391459 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone | HCID 12391492 | 18.2% |
반응 단계
A solution containing 4.6g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04090861 |
| 출처 데이터셋 | uspto-grants-1978_05 |
| ORD ID | ord-2005a2a0641041d69c36b39cd9a7f613 |
| 출처 메모 | uspto-grants-1978_05 |