Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Barium Oxide Nanoparticle Dispersion | HCID 9855530 | — |
| 반응물 | Tetramethylbenzyl ammonium hydroxide | HCID 19860286 | — |
| 생성물 | 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione | HCID 2729247 | — |
반응 단계
The above procedure is repeated in all respects, excepting that the strong base reagent is altered. In separate experiments, sodium hydride, potassium hydroxide, barium oxide, diisopropylethylamine, 1,5-diazobicyclo[5.4.0]undicene-5, tetramethylguanidine, tetramethylbenzyl ammonium hydroxide, Amberlite A21 (Rohm & Haas) strongly basic ion exchange resin and p-toluenesulfonic acid, are substituted for sodium hydroxide and yield the desired 3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione. In practice of the above-described method, sodium hydroxide or sodium hydride in refluxing toluene is preferred.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04090860 |
| 출처 데이터셋 | uspto-grants-1978_05 |
| ORD ID | ord-09779e0dd3804a56939db99ef28dec46 |
| 출처 메모 | uspto-grants-1978_05 |