4-Hydroxy-3-(2-propen-1-yl)benzyl alcohol → 4-(Hydroxymethyl)-2-propylphenol

HRID 37235노트

반응식

HRID 37235 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[CH2:10][CH:11]=[CH2:12].[H][H]>C(O)C.[Rh]>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 2

HCID 539952564-Hydroxy-3-(2-propen-1-yl)benzyl alcoholHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 220112094-(Hydroxymethyl)-2-propylphenol

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 702Ethanol용매

실험 절차

To a solution of 0,370 g (2.25 mmol) of the product of Step E dissolved in 25 mL of absolute ethanol was added 53 mg of a 5% rhodium on carbon catalyst and the mixture was shaken under a 40 psig pressure of hydrogen on a Parr apparatus. After 30 minutes, the reaction mixture was removed, filtered and evaporated in vacuo. The residue was purified on a silica gel flash chromatography column eluted with 35% ethyl acetate/hexane to afford the title compound.

후처리

  1. customthe reaction mixture was removed
  2. filtrationfiltered
  3. customevaporated in vacuo
  4. customThe residue was purified on a silica gel flash chromatography column
  5. washeluted with 35% ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-f4a71d73f16b48ffb7d5c974c2818f0f
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420133

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