Sodium Methoxide → Nalpha-[3-Mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-arginine

HRID 372383노트

반응식

HRID 372383 반응식
C([S:4][CH2:5][CH:6]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[C:7]([NH:9][C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:17])[NH2:16])=[O:8])(=O)C.C[O-].[Na+]>CO>[SH:4][CH2:5][CH:6]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[C:7]([NH:9][C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:16])[NH2:17])=[O:8]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 178500599HCID 178500599, 화합물

생성물 1

HCID 178500645Nalpha-[3-Mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-arginine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of Nα -[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-arginine (1.9 g.) in methanol (10 ml.), sodium methoxide (0.56 g.) is added. After ten minutes, the solution is applied to a column of Dowex 50 resin and the column is washed with water until no more acidic material is eluted. Nα -[3-mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-arginine is then eluted with a pyridine-acetate buffer of pH 6.5.

후처리

  1. waitAfter ten minutes
  2. washthe column is washed with water until no more acidic material
  3. washis eluted
  4. washNα -[3-mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-arginine is then eluted with a pyridine-acetate buffer of pH 6.5

출처 및 근거

ORD 기록
ord-49206b6456694438b22056b01169d680
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04091024

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