3-Chloro-1-propanol → 3-{4-[2-Chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol

HRID 372435노트

반응식

HRID 372435 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:10][C:4]=2[CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][OH:27]>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:12][CH2:13][N:14]([CH2:24][CH2:25][CH2:26][OH:27])[CH2:15][CH2:16]3)[CH2:10][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 123133-Chloro-1-propanolHCID 227679431-[2-Chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine

생성물 1

HCID 203151243-{4-[2-Chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol

실험 절차

In an analogous manner to that described in Example 5, from 1-[2-chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine and 3-chloro-1-propanol, there is obtained 3-{4-[2-chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol as an oil. The dihydrochloride, prepared in ethanol, melts at 206°-207° C (with decomposition).

출처 및 근거

ORD 기록
ord-ed29b1b0845d49d78ba83026269a7a57
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04091023

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