Isopropylamine → 4-Chloro-2-(1-cyano-1-methylpropylamino)-6-cyclopropylamino-5-pyrimidinecarbonitrile

반응식

[CH:1]1([NH2:4])[CH2:3][CH2:2]1.Cl[C:6]1[C:11]([C:12]#[N:13])=[C:10]([Cl:14])[N:9]=[C:8]([NH:15][C:16]([C:19]#[N:20])([CH3:18])[CH3:17])[N:7]=1.[CH:21](N)(C)C>>[Cl:14][C:10]1[C:11]([C:12]#[N:13])=[C:6]([NH:4][CH:1]2[CH2:3][CH2:2]2)[N:7]=[C:8]([NH:15][C:16]([C:19]#[N:20])([CH3:18])[CH2:17][CH3:21])[N:9]=1

참가 물질

반응물 3

HCID 6363Isopropylamine

HCID 69828Cyclopropylamine

HCID 537123174,6-Dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile

생성물 1

HCID 537277614-Chloro-2-(1-cyano-1-methylpropylamino)-6-cyclopropylamino-5-pyrimidinecarbonitrile

실험 절차

This compound was prepared in the manner of Example X, substituting 4,6-dichloro-2-(1-cyano-1-methylpropylamino)-5-pyrimidinecarbonitrile and cyclopropylamine for 4, 6-dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from carbon tetrachloride to give 4-chloro-2-(1-cyano-1-methylpropylamino)-6-cyclopropylamino-5-pyrimidinecarbonitrile; mp, 155°-159°.