Isopropylamine → 4-Chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile

HRID 372650노트

반응식

HRID 372650 반응식
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.Cl[C:6]1[C:11]([C:12]#[N:13])=[C:10]([Cl:14])[N:9]=[C:8]([NH:15][CH2:16][CH3:17])[N:7]=1.[CH:18](N)(C)C>>[Cl:14][C:10]1[C:11]([C:12]#[N:13])=[C:6]([NH:4][CH:1]2[CH2:3][CH2:2]2)[N:7]=[C:8]([NH:15][CH:16]([CH3:17])[CH3:18])[N:9]=1

참가 물질

4

반응물 3

HCID 6363IsopropylamineHCID 69828CyclopropylamineHCID 205102564,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile

생성물 1

HCID 205102674-Chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile

실험 절차

This compound was prepared in the manner of Example XVII, substituting 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile and cyclopropylamine for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine, producing 4-chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile. Upon recrystallization from methylcyclohexane, the melting point was 157°-160°.

후처리

  1. customThis compound was prepared in the manner of Example XVII

출처 및 근거

ORD 기록
ord-7fbe24f0a8654fd9ab27be8b7d876e6f
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092150

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