Acetic Acid → 6-(4-Bromophenyl)-2,3-dihydropyridazin-3-one

HRID 372689

반응식

HRID 372689 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.C(O)(=O)C.BrBr>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 176Acetic Acid2회HCID 24408BromineHCID 6891086-(4-Bromophenyl)-4,5-dihydropyridazin-3(2H)-one

생성물 1

HCID 6890736-(4-Bromophenyl)-2,3-dihydropyridazin-3-one

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 86.3 g of 6-(p-bromophenyl)-4,5-dihydro-3(2H)-pyridazinone (prepared as described in Example 5 of U.S. Pat. No. 3,689,652) in 500 ml. of glacial acetic acid is heated to 80° C. with continuous stirring. A solution of 60 g. (19.2 ml) of bromine in 80 ml. of acetic acid is added dropwise at 75°-80° C. over a period of 1 hour. The mixture is heated with stirring on a steam bath for 1/2 hour more and then poured into 3 liters of cracked ice and water. The white solid is collected by filtration and air dried, yielding 6-(p-bromophenyl)-3(2H)-pyridazinone.

후처리

  1. customprepared
  2. temperatureThe mixture is heated
  3. filtrationThe white solid is collected by filtration and air
  4. customdried

출처 및 근거

ORD 기록
ord-83cb8a8b390043a18ed0dbc1f91b07a2
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092311

연결된 노트

불러오는 중…