Ammonium Hydroxide → 5-methyl-6-phenyl-3(2H)-Pyridazinone
반응식
[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:15])[CH:3]=1.[OH-].[NH4+].[H][H]>[Pd].C(O)C>[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:15])[CH:3]=1참가 물질
6
반응 조건
- 온도
- 50 °C
실험 절차
A 10.0 g. portion of 5-methyl-6-p-bromophenyl-3(2H)-pyridazinone and 1.0 g. of 10% palladium on carbon catalyst in 150 ml. of ethanol and 50 ml. of ammonium hydroxide is shaken under 40 lb. of hydrogen pressure for 4 hours in a Parr bottle, heated to 50° C. with an outside jacket. The reaction mixture is suction filtered and the filtrate concentrated to a white solid which is washed with water and air dried to afford 5-methyl-6-phenyl-3(2H)-pyridazinone as white crystals.
후처리
- filtrationfiltered
- concentrationthe filtrate concentrated to a white solid which
- washis washed with water and air
- customdried
출처 및 근거
- ORD 기록
- ord-d49d3470fa454469ba9a7803968e1111
- 출처 데이터셋
- uspto-grants-1978_05
- 특허 번호
- US04092311
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