5-Bromo-2-hydroxypyridine → 5-(Phenylthio)-2-pyridone

HRID 372733

반응식

HRID 372733 반응식
Br[C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[S-:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[K+]>CN1CCCC1=O.O>[C:10]1([S:9][C:2]2[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

5

반응물 2

HCID 5995285-Bromo-2-hydroxypyridineHCID 11789364benzenethiol, potassium salt

생성물 1

HCID 203265625-(Phenylthio)-2-pyridone

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

A solution of 5-bromo-2-pyridone (17.3 g 0.1 mole) in N-methylpyrrolidinone (250 ml.) and potassium thiophenoxide (18.1 g, 0.12 mole) is heated at reflux for 12 hours under a nitrogen atmosphere. The reaction mixture is cooled and diluted with water. The product is collected by filtration, washed with water and dried to yeild 5-(phenylthio)-2-pyridone.

후처리

  1. temperatureat reflux for 12 hours under a nitrogen atmosphere
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe product is collected by filtration
  4. washwashed with water
  5. dry with materialdried to yeild 5-(phenylthio)-2-pyridone

출처 및 근거

ORD 기록
ord-9ca0a3824ae444c9b4fee4d9894b9db9
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092321

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