Acetate → HCID 70619535, 화합물

HRID 372778노트

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HRID 372778 반응식
Cl.[NH2:2][C@H:3]([C:12]([NH:14][CH2:15][C:16]([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:34]([NH:36][C@H:37]([C:42]([OH:44])=[O:43])[CH2:38][CH2:39][S:40][CH3:41])=[O:35])[CH2:24][C:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[NH:27][CH:26]=1)=[O:21])=[O:17])=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.C([O-])(=O)C>C(O)(=O)C>[C:42]([OH:44])(=[O:43])[CH3:37].[NH2:2][C@H:3]([C:12]([NH:14][CH2:15][C:16]([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:34]([NH:36][C@H:37]([C:42]([OH:44])=[O:43])[CH2:38][CH2:39][S:40][CH3:41])=[O:35])[CH2:24][C:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[NH:27][CH:26]=1)=[O:21])=[O:17])=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 175AcetateHCID 70620434HCID 70620434, 화합물

생성물 1

HCID 70619535HCID 70619535, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

17.3 Parts L-tyrosylglycylglycyl-L-tryptophyl-L-methionine hydrochloride is dissolved in 250 parts by volume of 20% acetic acid and passed slowly through an IR-45 ion exchange column in the acetate form. The column is washed with 20% acetic acid until no more peptide is eluted. Fractions containing the product are combined and the solvent removed by stripping under reduced pressure at room temperature. The residual glass is dissolved in 75 parts water and lyophilized to give L-tyrosylglycylglycyl-L-tryptophyl-L-methionine acetic acid salt. This compound is represented by the following formula

후처리

  1. washThe column is washed with 20% acetic acid until no more peptide
  2. washis eluted
  3. additionFractions containing the product
  4. customthe solvent removed
  5. customby stripping under reduced pressure at room temperature
  6. dissolutionThe residual glass is dissolved in 75 parts water

출처 및 근거

ORD 기록
ord-b6539617919848d1a54a7a3195315bce
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092304

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