Benzyl L-leucinate → N-t-butoxycarbonylglycyl-L-leucine benzyl ester

HRID 372783노트

반응식

HRID 372783 반응식
ClC1C=C(Cl)C(Cl)=CC=1[O:10][C:11](=O)[CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].[CH2:22]([O:29][C:30](=[O:37])[C@H:31]([CH2:33][CH:34]([CH3:36])[CH3:35])[NH2:32])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(Cl)Cl>[CH2:22]([O:29][C:30](=[O:37])[C@H:31]([CH2:33][CH:34]([CH3:35])[CH3:36])[NH:32][C:11](=[O:10])[CH2:12][NH:13][C:14]([O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:15])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

4

반응물 2

HCID 6451313Benzyl L-leucinateHCID 12799284t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl Ester

생성물 1

HCID 53703413N-t-butoxycarbonylglycyl-L-leucine benzyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 19.5 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 11.1 parts L-leucine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. The solvent is then removed by evaporation under reduced pressure. The crude dipeptide is then subjected to low-pressure column chromatography on silica gel to afford N-t-butoxycarbonylglycyl-L-leucine benzyl ester.

후처리

  1. customThe solvent is then removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-0ac71ffc126449cab9a5591baaaff651
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092304

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