Aminoacetonitrile → n-(Cyanomethyl)-3-oxobutanamide

HRID 372825

반응식

HRID 372825 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][C:9]#[N:10]>CO>[C:8]([CH2:9][NH:10][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])#[N:7]

참가 물질

4

반응물 2

HCID 10901AminoacetonitrileHCID 12661Diketene

생성물 1

HCID 225301n-(Cyanomethyl)-3-oxobutanamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

While stirring at -10° to 0° C, 92 g of freshly distilled diketene are added dropwise to a solution of 400 ml of methanol and 56 g of freshly distilled aminoacetonitrile. The mixture is allowed to warm to room temperature and stirring is continued for 2 hours at 35° C in a water bath. The solvent is distilled off by rotary evaporation and the solid residue is suspended in cold ether. Suction filtration yields the colourless, crystalline, pure acetoacetic N-cyanomethylamide with a melting point of 63°-65° C.

후처리

  1. stirringstirring
  2. distillationThe solvent is distilled off by rotary evaporation
  3. filtrationSuction filtration

출처 및 근거

ORD 기록
ord-edf8403fec024ca0b4dada8603fe6c81
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092415

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