Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexanone → 3,4-dihydro-6-(1,1-dimethylethyl)-8-iodospiro[2H-1,3-benzoxazine-2,1'-cyclohexane]
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexanone | HCID 7967 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | 2-Aminomethyl-4-t-butyl-6-iodophenol | HCID 119286 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3,4-dihydro-6-(1,1-dimethylethyl)-8-iodospiro[2H-1,3-benzoxazine-2,1'-cyclohexane] | HCID 12857892 | 72.7% |
반응 단계
A mixture of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol (1.5 g., 0.005 mole), cyclohexanone (0.5 g., 0.005 mole), and magnesium sulfate (0.5 g.) in tetrahydrofurane (50 ml.) is kept under nitrogen at 20°-25° C., for 16 hours. The magnesium sulfate is removed and the filtrate evaporated to dryness. The residue is crystallized from ethanol to obtain 3,4-dihydro-6-(1,1-dimethylethyl)-8-iodospiro[2H-1,3-benzoxazine-2,1'-cyclohexane] (1.4 g.), m.p. 112°-114° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04092414 |
| 출처 데이터셋 | uspto-grants-1978_05 |
| ORD ID | ord-5aea0e76281a433ea39b979896e6e638 |
| 출처 메모 | uspto-grants-1978_05 |