Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrazole → 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrazole | HCID 1048 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(4-(4-Bromobutyl)piperazin-1-yl)pyrimidine | HCID 14726843 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole | HCID 11044366 | — |
반응 단계
A mixture of 4 g (13.3 mmol) of 1-(2-pyrimidinyl)-4-(4-bromobutyl)piperazine, 1.02 g (15 mmol) of pyrazole and 2.76 g (20 mmol) of potassium carbonate in 50 ml of dimethylformamide is heated to reflux for 14 hours. The mixture is evaporated under vacuum, chloroform is added, the organic phase is washed with water, dried over sodium sulphate and evaporated under vacuum, and 3.5 g of an oil which is 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05162323 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-88d5f208d48e4fefa8dfa751ff185f9e |
| 출처 메모 | uspto-grants-1992_11 |