Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride etherate → Cyclododecanecarboxaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | 1-Oxaspiro[2.11]tetradecane | HCID 11019800 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Cyclododecanecarboxaldehyde | HCID 78737 | 34% |
반응 단계
To 5.0 g (25.5 mmol) of 1-oxaspiro[2.11]tetradecane in 50 ml of dry ether at 0° C. is slowly added 1.8 ml (2.1 g, 14.6 mmol) of boron trifluoride etherate. The ice bath is removed and after 15 minutes at room temperature the solution is partitioned between ether and saturated sodium bicarbonate. The organic phase is evaporated to give a clear oil. Flash chromatography over silica gel using a hexane to hexane:ethyl acetate (9:1) gradient give 1.6 g (34%) of a clear oil: NMR (CDCl3) δ 1.28-1.8 (m, 18H), 2.03 (s, 1H), 2.42 (m, 1H), 9.62 (s, 1H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420153 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-2af3065affd844bd99ccf33cda805453 |
| 출처 메모 | uspto-grants-1995_05 |