Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Butanoic acid, 2-ethyl-3-oxo-, ethyl ester | HCID 79065 | — |
| 반응물 | Pentanimidamide Hydrochloride | HCID 11615174 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 2-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one | HCID 135625455 | — |
반응 단계
A solution of 3.0 g valeramidine hydrochloride, 3.47 g ethyl 2-ethylacetoacetate, and 5.8 mL triethylamine in 20 mL DMF was heated to 120° C. for 18 hours. The mixture was diluted with brine and extracted three times with ether. The combined organic material was washed with brine, was dried over MgSO4, was stripped of solvent in vacuo, and then was still flash chromatographed in 3% MeOH in CH2Cl2 to give the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05162325 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-2c1dd5fc50af494f8e30ecfcd63b6475 |
| 출처 메모 | uspto-grants-1992_11 |