Dimethylformamide → HCID 19811955, 화합물

HRID 373144노트

반응식

HRID 373144 반응식
[SH:1][C:2]1[O:3][C:4]([C:7]2[O:11][C:10]([N:12]([CH3:14])[CH3:13])=[N:9][N:8]=2)=[N:5][N:6]=1.O1CCOCC1.CN(C)C=O.Br[CH2:27][CH2:28][C:29]([F:33])=[C:30]([F:32])[F:31]>O>[F:33][C:29](=[C:30]([F:32])[F:31])[CH2:28][CH2:27][S:1][C:2]1[O:3][C:4]([C:7]2[O:11][C:10]([N:12]([CH3:14])[CH3:13])=[N:9][N:8]=2)=[N:5][N:6]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 312751,4-DioxaneHCID 663334-Bromo-1,1,2-trifluorobut-1-eneHCID 178483107HCID 178483107, 화합물

생성물 1

HCID 19811955HCID 19811955, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4.26 g of 2-mercapto-5-(2-dimethylamino-1,3,4-oxadiazol-5-yl)-1,3,4-oxadiazole according to Example H2 are initially introduced into 40 ml of dioxane and stirred with 2.24 g of potassium t-butylate. 4 ml of dimethylformamide and then 4.2 g of 4-bromo-1,1,2-trifluorobut-1-ene are added and the mixture is stirred overnight at room temperature. The mixture is poured into water and the crystals are filtered off with suction. After drying and stirring with ether, 4.6 g of the title compound of melting point 87°-90° C. are obtained.

후처리

  1. filtrationthe crystals are filtered off with suction
  2. customAfter drying
  3. stirringstirring with ether, 4.6 g of the title compound of melting point 87°-90° C.
  4. customare obtained

출처 및 근거

ORD 기록
ord-cb0458332f62444597fd8cc0e25ef86f
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162349

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