Nitric Acid → HCID 14817081, 화합물

HRID 373444노트

반응식

HRID 373444 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][C:6]=1[F:15])(=[O:3])[CH3:2].[N+:16]([O-])([OH:18])=[O:17]>C(O)(=O)C>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([N+:16]([O-:18])=[O:17])[C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][C:6]=1[F:15])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 148170801,4-Bisacetylamino-2-fluorobenzene

생성물 1

HCID 14817081HCID 14817081, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

반응 조건

온도
40 °C

실험 절차

157.5 g (0.75 mol) of the 1,4-bisacetylamino-2-fluorobenzene obtained above under B. are initially introduced into 630 g of glacial acetic acid, and a mixture of 42 g of glacial acetic acid and 51 g of nitric acid (density 1.5) is added dropwise in the course of 2 hours. The mixture is subsequently stirred at 40° C. for a further 2 hours and cooled to 15° C. After the product which has precipitated has been filtered off, it is washed twice with 50 ml of glacial acetic acid each time and dried at 50° C. in a vacuum cabinet.

후처리

  1. additionis added dropwise in the course of 2 hours
  2. temperaturecooled to 15° C
  3. customAfter the product which has precipitated
  4. filtrationhas been filtered off
  5. washit is washed twice with 50 ml of glacial acetic acid each time
  6. customdried at 50° C. in a vacuum cabinet

출처 및 근거

ORD 기록
ord-dca34d19e2db408d81b64814efeffab2
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05163970

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