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HCID 13891111, 화합물 → (3S,4S)-3-Hydroxy-4-amino-5-cyclohexyl-1-pentene

HRID 373641
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HRID 373641 반응식
[CH:1]1([CH2:7][C@H:8]2[CH:12]([CH:13]=[CH2:14])[O:11]C(=O)[NH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-]>O1CCOCC1.O>[OH:11][C@H:12]([C@@H:8]([NH2:9])[CH2:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH:13]=[CH2:14]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 13891111HCID 13891111, 화합물HCID 17749109Barium hydroxide, octahydrate

생성물 1

HCID 14478714(3S,4S)-3-Hydroxy-4-amino-5-cyclohexyl-1-pentene

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

To the resultant 5S-diastereomer from Example 4 (2.06 g, 9.84 mmol) in dioxane (180 ml) and water (120 ml) was added barium hydroxide octahydrate (6.24 g, 19.8 mmol). The mixture was refluxed for 18 h, cooled, filtered, concentrated, taken up in water and extracted with ethyl acetate which was dried over Na2SO4 and evaporated to afford 1.64 9 (91%) of the desired product, m.p.: 59°-61° C.

후처리

  1. temperatureThe mixture was refluxed for 18 h
  2. temperaturecooled
  3. filtrationfiltered
  4. concentrationconcentrated
  5. extractionextracted with ethyl acetate which
  6. dry with materialwas dried over Na2SO4
  7. customevaporated

출처 및 근거

ORD 기록
ord-d221a7cb9bae4fc09a44956c6d96a3ae
출처 데이터셋
uspto-grants-1992_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05164388

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