Nitric Acid → 6-Nitroquinolin-2(1H)-one

HRID 373783노트

반응식

HRID 373783 반응식
[N+:1]([O-:4])(O)=[O:2].[OH:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1.O>S(=O)(=O)(O)O>[N+:1]([C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:5])[CH:15]=[CH:14]2)([O-:4])=[O:2]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 962WaterHCID 178515546HCID 178515546, 화합물

생성물 1

HCID 8999326-Nitroquinolin-2(1H)-one수율 67%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Nitric acid (70%), 2.3 mL, was added dropwise to a stirred mixture of 2-hydroxyquinoline (available commercially or by one of the methods described in Beilstein 21, 77) 3.5 g (0.024 mole), in 20 mL of concentrated sulfuric acid at 0° C. The reaction mixture was stirred for 2 hours at room temperature and then poured into ice and water. The resulting solid was collected by filtration, washed with cold water and then digested twice with hot methanol to yield 3 g (67%) of 6-nitrocarbostyril as crystals; m.p. 280°-282° C.

후처리

  1. customat 0° C
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with cold water

출처 및 근거

ORD 기록
ord-2412aafaf56549e5bdaf68fac399747d
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166160

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