Phenylhydrazine → HCID 86746349, 화합물

반응식

[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[C:16](=O)[CH3:17]>>[C:1]1([NH:7][N:8]=[C:16]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:10]=2[NH2:9])[CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 7516Phenylhydrazine2회

HCID 107730271-(4-Amino-3-pyridinyl)ethanone2회

생성물 1

HCID 86746349HCID 86746349, 화합물

반응 조건

온도: 100 °C

실험 절차

Phenylhydrazine (4.0 ml) was added to 5.00 g 1-(4-amino-3-pyridinyl)ethanone, and the mixture was stirred at 100° C. for seventeen hours. A similar procedure was followed using 4.0 g 1-(4-amino-3-pyridinyl)ethanone and 3.20 ml phenylhydrazine. The products of the two reactions were combined and purified by flash chromatography to yield 9.74 g solid. Recrystallization of 1.24 g from CH3OH/water yielded 0.28 g solid, m.p. 168°-170° C.

후처리

custompurified by flash chromatography

출처 및 근거

ORD 기록: ord-79ba4b5c1ead43e1b90eccf3031cce4c
출처 데이터셋: uspto-grants-1992_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05166170

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